Propolis: The Chemopreventative Anticancer Drug

The anti-tumor effects of Propolis are verified once again in detail. This protector of the beehive is the natural protector for all mankind and all in the animal kingdom... 

The Anticancer Activity of Propolis

FoliaHistochem Cytobiol, 2012 Apr
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Abstract:

Propolis and its compounds have been the subject of many studies due to their antimicrobial and antiinflammatory activity; however, it is now known that they also possess antitumor properties.

This review aims to summarize the results of studies on the mechanism of activity of propolis and its active compounds such as CAPE and chrysin in the apoptotic process, and their influence on the proliferation of cancer cells.

Our review shows that propolis and its presented compounds induce apoptosis pathways in cancer cells. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest.

The results of in vitro and in vivo studies suggest that propolis, CAPE and chrysin may inhibit tumor cell progression and may be useful as potential chemotherapeutic or chemopreventive anticancer drugs...

Conclusion: 

With an increasing incidence rate of cancer worldwide, new anticancer agents are still required. One of the benefits of anticancer therapy is the ability to initiate apoptosis and cell cycle arrest in cancer cells. The studies presented in this review suggest that propolis and its compounds, CAPE and chrysin, may inhibit cell cycle proliferation or induce apoptosis in tumor cells...