As usual, Propolis proves its functionality in a mucuos environment with anti-inflammatory activity. I wonder if CAPE will also exhert its anti-tumor properties at the same time...
Catechols in Caffeic Acid Phenethyl Ester are Essential for Inhibition of TNF-Mediated IP-10 Expression Through NF-κB-Dependent But HO-1- and p38-Independent Mechanisms in Mouse Intestinal Epithelial Cells
Molecular Nutritional Food Research, Oct 31 2011
Caffeic acid phenethyl ester (
CAPE) is an active constituent of honeybee propolis inhibiting nuclear factor (NF)-κB. The aims of our study were to provide new data on the functional relevance and mechanisms underlying the role of CAPE in regulating inflammatory processes at the epithelial interface in the gut and to determine the structure/activity relationship of CAPE.
Methods and results:
We found that
CAPE did not inhibit TNF-induced IκB phosphorylation/degradation or nuclear translocation of RelA/p65, but targeted downstream signaling events at the level of transcription factor recruitment to the gene promoter.
This study reveals the structure-activity effects and anti-inflammatory potential of
CAPE in the intestinal epithelium.