Wednesday, May 29, 2013

Royal Jelly Prevents Geriatric Muscle Loss

This important study confirms yet another aspect of Royal Jelly's anti-aging effectiveness in preventing issues such as muscle loss (Sarcopenia), mental clarity (Parkinsons, Alzheimers), skin conditions, lack of vitality, etc. Other studies on this blog, confirm the positive results in combating these problems through the consumption of Royal Jelly...

Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells.

Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice.

In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls.

These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.

Friday, May 24, 2013

Propolis Ointment Accelerates Wound Healing

Well known for it's anti-inflammatory and antimicrobial properties, propolis also stimulates wound healing, cell metabolism and circulation...

Topical Treatment of Nonhealing Venous Leg Ulcer with Propolis Ointment

An investigation of effectiveness of topical treatment of nonhealing chronic venous leg ulcers with propolis ointment was conducted. 56 patients were included in the study and randomized into two groups.

In group 1, there were 28 patients (ulceration area: 6.9-9.78 cm(2)) treated by means of topical propolis ointment application and short stretch bandage compression. In group 2, there were 29 patients (ulceration area: 7.2-9.4 cm(2)) treated by means of Unna boot leg compression without topical propolis treatment. In the study, the efficacy of both treatment methods in patients with resistive venous leg ulcers was compared.

The ulceration of patients from group 1 healed completely after 6 weeks of therapy in all cases. In all patients from group 2, the process of healing was longer but successfully completed after 16 weeks of the therapy.

We found that an adjunctive propolis ointment treatment increases the efficacy of the short stretch bandage compression stocking, and this combined treatment is more effective than Unna's boot compression alone...

“The propolis skin cream appears to have beneficial effects on burn wounds, inflammation of the skin, and other skin lesions. According to the results of our study, it can also be concluded that propolis skin ointment appears to have beneficial effects on healing venous ulcers. Propolis has been shown to stimulate various enzyme systems, cell metabolism, circulation, and collagen formation as well as improve the healing of burn wounds…”

Another study of topical application of propolis on wounds, burns, and ulcers showed up to an 80% accelerated healing process compared to the controls using routine healing regimes. Treated individuals (229 patients in total) underwent applications of the propolis containing cream at two propolis concentrations (2% and 8%). The higher concentration caused local intolerance in 18% of patients by day 9, whereas the lower concentration caused adverse symptoms in only 1.8% of patients by day 16…”

Monday, May 13, 2013

Propolis: Adjuvant Agent for Cancer Prevention

Honeybees have been using the resin that protects tree buds from disease for preventative action in their hives. It's now recognized by humans for having therapeutic and preventative effects. I wonder what else we could learn from honey bees...

Clinical Reviews in Allergy & Immunology
June 2013, Volume 44, Issue 3, pp 262-273

Propolis, a waxy substance produced by the honeybee, has been adopted as a form of folk medicine since ancient times. It has a wide spectrum of alleged applications including potential anti-infection and anticancer effects. Many of the therapeutic effects can be attributed to its immunomodulatory functions. The composition of propolis can vary according to the geographic locations from where the bees obtained the ingredients.

Two main immunopotent chemicals have been identified as caffeic acid phenethyl ester (CAPE) and artepillin C. Propolis, CAPE, and artepillin C have been shown to exert summative immunosuppressive function on T lymphocyte subsets but paradoxically activate macrophage function. On the other hand, they also have potential antitumor properties by different postulated mechanisms such as suppressing cancer cells proliferation via its anti-inflammatory effects; decreasing the cancer stem cell populations; blocking specific oncogene signaling pathways; exerting antiangiogenic effects; and modulating the tumor microenvironment.

The good bioavailability by the oral route and good historical safety profile makes propolis an ideal adjuvant agent for future immunomodulatory or anticancer regimens. However, standardized quality controls and good design clinical trials are essential before either propolis or its active ingredients can be adopted routinely in our future therapeutic armamentarium. 

Wednesday, May 8, 2013

Royal Jelly Protection from Radiation Therapy

One element we consistently find in studies is the protective properties of honey bee products. Now, more proof of Royal Jelly's protective effects from radiation or Radiotherapy. These protective qualities are also true with Honey, Propolis, Bee Pollen and when combined generate a Synergistic effect enhancing all their protective properties...

Effect of Royal Jelly on Serum Trace Elements in Rats Undergoing Head and Neck Irradiation
Kulak BurunBogaz Ihtis Derg, 2013 Jan-Feb;23(1):37-43

This study aims to investigate the effects of radiation on serum trace elements and the changes in these elements as induced by royal jelly in rats undergoing head and neck irradiation.

Thirty-two Sprague-Dawley male rats at the age of eight weeks with a mean weight of 275±35 g were included in the study. Subjects were divided into four groups with eight rats in each group: group 1: controls (C), group 2: radiation-only (RT), group 3: radiation plus royal jelly 50 mg/kg (RT+RJ50) and group 4: royal jelly 50 mg/kg-only (RJ50). Radiotherapy was applied to the head and neck area by single fraction at a dose of 22 Gy. The royal jelly was given once daily for seven days. The subjects were sacrificed on the seventh day of the study. Trace elements in blood samples were measured using ICP/MS method.

When the trace element levels among the groups were compared using ANOVA test, a statistically significant difference was found in Al, As, Ca, Cd, Cr, K, Mg, Pb, Se, and Sn levels. No significant difference was found in the levels of Ag, Ba, Co, Cs, Cu, Fe, Ga, Hg, Mn, Na, Ni, Rb, Sr, Ti, U, V, and Zn (p > 0.05). It was observed that oxidative stress was reduced in the radiation plus royal jelly group, compared to the radiation-only group.

Our study results suggest that head and neck irradiation increases oxidative stress, leading to some changes in the trace element levels, while royal jelly exhibits a protective effect against the oxidative stress induced by radiation.