Propolis contains up to 10% essential oils, more in quantity than most aromatic plants. This could explain why each time we smell propolis or air from the beehive, we experience a nice, relaxing sensation...
Therapeutic Effects of Propolis Essential Oil on Anxiety of Restraint-Stressed Mice
Hum Exp Toxicol, 2012, February
Propolis has a broad spectrum of biological activities; however, whether its essential oils have neuroprotective effects is unknown.
In this study, we found that propolis essential oil (PEO) could significantly reverse the anxiety-like behavior of restraint-stressed mice, and has no effect on locomotor activity. Furthermore, PEO significantly decreased the plasma levels of cortisol (CORT), adrenocorticotropic hormone (ACTH) and malondialdehyde (MDA), whereas it increased the activity of superoxide dismutase (SOD) in restraint-stressed mice.
These results strongly suggest that PEO has therapeutic effects on anxiety through antagonizing the hyperfunction of hypothalamic–pituitary–adrenal (HPA) axis and improving the ability of antioxidation in brain tissue.