Thursday, May 24, 2018

Honey: A Healthy Choice for Diabetics

This published article reviews all studies that validate honey as a novel anti-diabetic agent. To no surprise, honey has been revered as a naturally, preferred sweetner for diabetics, simply for the fact that it doesn't require insulin to be digested. This peer-reviewed article from Romanian faculty is very qualified to digest the data for the intrinsic value contained within.

Honey and Diabetes: The Importance of Natural Simple Sugars in Diet for Preventing and Treating Different Type of Diabetes


Diabetes is a metabolic disorder with multifactorial and heterogeneous etiologies. Two types of diabetes are common among humans: type 1 diabetes that occurs when the immune system attacks and destroys insulin and type 2 diabetes, the most common form, that may be caused by several factors, the most important being lifestyle, but also may be determined by different genes.

Honey was used in folk medicine for a long time, but the health benefits were explained in the last decades, when the scientific world was concerned in testing and thus explaining the benefits of honey.


Different studies demonstrate the hypoglycemic effect of honey, but the mechanism of this effect remains unclear.


This review presents the experimental studies completed in the recent years, which support honey as a novel antidiabetic agent that might be of potential significance for the management of diabetes and its complications and also highlights the potential impacts and future perspectives on the use of honey as an antidiabetic agent.

Download the complete article here.

Friday, April 27, 2018

Propolis: A Natural Healer of Gastrointestinal Diseases

Propolis heals and protects - both in the hive and within living beings. Previous studies also confirm the effectiveness of its therapeutic properties on mucous linings of the body. Not surprising that its anti-inflammatory effects on gastrointestinal diseases.


Propolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases


Journal of Applied BiomedicineAbstract:
Helicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. 
Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very effective in eradicating H. pylori infections. The quest for an alternative treatment free of these inconveniences is currently in demand. One of the important alternatives is propolis, produced by the honeybee Apis mellifera, which has been used to treat different diseases since it possesses a wide range of biochemical properties.

Propolis has been reported as a useful therapeutic regimen against H. pylori, which is an important cause of gastric inflammation, peptic ulcer, gastric cancer, and lymphomas of mucosa-associated lymphoid tissues. Apart from propolis, various active compounds of other natural products have also been confirmed to be effective. This review compiles the scientific evidence of the role of propolis and other natural products against H. pylori-associated gastrointestinal tract-related health complexities by acting as an anti-angiogenic, anti-inflammatory, and antioxidant factor as well as via modulation of enzymatic activities.


Thursday, March 15, 2018

Propolis: Potential Solution to Gluten-induced Celiac Disease

The anti-inflammatory effects of propolis are well-documented, especially on mucous linings of the body. This study reaffirms its capacity to reduce inflammation while also diminishing nitric oxide synthase, another inflammatory factor in septic shock, auto-immune diseases or proinflammatory cytokine production.

Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway


Celiac Disease (CeD) is a chronic immune-mediated enteropathy, in which dietary gluten induces an inflammatory reaction, predominantly in the duodenum. Propolis is a resinous hive product, collected by honeybees from various plant sources.

Propolis is well-known for its anti-inflammatory, anti-oxidant and immunomodulatory effects, due to its major compounds, polyphenols and flavonoids. The aim of our study was to assess the ex vivo effect of ethanolic extract of propolis (EEP) upon the activity and expression of iNOS, along with IFN-γ and IL-10 production in Algerian Celiac patients. In this context, PBMCs isolated from peripheral blood of Celiac patients and healthy controls were cultured with different concentrations of EEP. NO production was measured using the Griess method, whereas quantitation of IFN-γ and IL-10 levels was performed by ELISA. Inducible nitric oxide synthase (iNOS) expression, NFκB and pSTAT-3 activity were analyzed by immunofluorescence assay.

Our results showed that PBMCs from Celiac patients produced high levels of NO and IFN-γ compared with healthy controls (HC). Interestingly, EEP reduced significantly, NO and IFN-γ levels and significantly increased IL-10 levels at a concentration of 50 µg/mL. Importantly, EEP downmodulated the iNOS expression as well as the activity of NFκB and pSTAT-3 transcription factors.

Altogether, our results highlight the immunomodulatory effect of propolis on NO pathway and on pro-inflammatory cytokines. Therefore, we suggest that propolis may constitute a potential candidate to modulate inflammation during Celiac Disease and has a potential therapeutic value.


Sunday, October 29, 2017

Functional Food for Better Health - Honey, Propolis & Royal Jelly

Its all in the ingredients!! Each of these products merit healthy respect but all three together? In Apitherapy, that's called Synergistic Power! If you're consuming these bee products, you're not only saving your life but helping bees maintain an important role and contributor to all beings on our planet. 

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits
JOxidMed 2017 February

Introduction
Apiculture is the science and art of prolonging, sustaining, and retaining health by using products obtained from honeybee hives, such as honey, bee bread, bee venom, bee pollen, propolis, and royal jelly. Recent years have seen the fast application of bee products in both traditional and modern medicine. Currently, many studies are targeted toward investigating directed health benefits and pharmacological properties of bee products due to their efficacies, leading to the increasing development of nutraceuticals and functional food from these products. The concept of functional food refers to food that has the ability to promote better physiological or psychological health compared to traditional remediated and nutritional food. These effects positively contribute toward excellent health maintenance, well-being, and reduced chronic illness [1]. The present review focuses on the potential health benefits of bee products, including honey, propolis, and royal jelly. 

Conclusion
The present review focused on the potential health benefits of bee products such as honey, propolis, and royal jelly. These products are highly rich in active components such as flavonoids, phenolic acid, phenolic compounds, terpenes, and enzymes, which have biological functions in preventing some diseases and promoting good health. Honey, propolis, and royal jelly have distinct efficacies with significant nutritional properties and functional values. Thus, these bee products can be developed into potent apitherapeutic agents. However, some precautions need to be taken in case of allergens associated with bee products and in finding the right intake dosage. Hence, it is necessary to conduct further studies to determine the critical mechanisms related to the pharmacological activities of these bee products and the appropriate amounts that can be taken in order to obtain promising health benefits.










Tuesday, September 26, 2017

Buckwheat Honey Exhibits Super Protective Effect

Generally speaking, the darker the honey the richer it is both in mineral content and therapeutic effect. Buckwheat honey has a history of it's beneficial value and this study confirms its high antioxidant activity and phenolic content. Though it may be strong in flavor for the palette, it's an ideal complement to a wound healing strategy.

The Protective Effect of Whole Honey and Phenolic Extract on Oxidative DNA Damage in Mice Lymphocytes Using Comet Assay


In this study, the antioxidant activity and the protective effect against hydrogen peroxide-induced DNA damage were assessed for five honeys of different botanical origin. Seven phenolic acids were detected in the honey samples. Ferulic acid was the most abundant phenolic acid detected in longan honey, jujube honey and buckwheat honey. Ellagic acid, p-hydroxybenzoic acid and protocatechuic acid were the main phenolic acids detected in vitex honey.

Of all honey samples tested, the highest total phenolic content and antioxidant activity were found in buckwheat honey, whereas the lowest total phenolic content and antioxidant activity were found in locust honey. Treatment with hydrogen peroxide induced a 62% increase in tail DNA in mice lymphocytes, and all studied honeys significantly inhibited this effect (P < 0.05).

The buckwheat honey with higher antioxidant capability also exhibited super protective effect than others. Phenolic extracts of honey displayed greater protective effects than whole honey in comet assay. The hydrogen peroxide-generated increase in 8-hydroxy-2-deoxyguanosine (8-OHdG) was effectively inhibited by the honeys studied (P < 0.05). Moreover, a dose-effect relationship between honey concentration and its protective effect was clearly observed in this study.


It can be deduced that phenolic acids of honey can penetrate into lymphocytes and protect DNA from oxidative damage by scavenging hydrogen peroxide and/or chelating ferrous ions.


Friday, September 30, 2016

Antimicrobial Effects of Royal Jelly Confirmed

Deserving of its name, Royal Jelly is indeed very remarkable! Not only does it provide hormonal support in men and women, acts as a "brain booster" aiding mental capacities, it also has significant antimicrobial force, especially against Gram positive bacteria. 

Royal Jelly: An Ancient Remedy with Remarkable Antibacterial Properties
Microbiol Res. 2016 Nov


Abstract
Royal Jelly (RJ), a honeybee hypopharyngeal gland secretion of young nurse and an exclusive nourishment for bee queen, has been used since ancient times for care and human health and it is still very important in traditional and folkloristic medicine, especially in Asia within the apitherapy.

Recently, RJ and its protein and lipid components have been subjected to several investigations on their antimicrobial activity due to extensive traditional uses and for a future application in medicine. Antimicrobial activities of crude Royal Jelly, Royalisin, 10-hydroxy-2-decenoic acid, Jelleines,

Major Royal Jelly Proteins against different bacteria have been reported. All these beehive products showed antimicrobial activities that lead their potential employment in several fields as natural additives. RJ and its derived compounds show a highest activity especially against Gram positive bacteria. The purpose of this Review is to summarize the results of antimicrobial studies of Royal Jelly following the timescale of the researches.

From the first scientific applications to the isolation of the single components in order to better understand its application in the past years and propose an employment in future studies as a natural antimicrobial agent.


Sunday, September 18, 2016

Honey is for Horses and Humans, Heals Wounds

The take-away from this study is that honey heals wounds, certainly raw honey (unheated & unfiltered) which contains Lactic Acid Bacteria. Many studies have demonstrated its healing capacity with regards to wounds but the researchers chose hard-to-heal wounds that took more than a year to heal! The results are very impressive, as antibiotic-resistant strains are becoming more commonplace in medical establishments.

Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria
Current Microbiology October 2016

In the global perspective of antibiotic resistance, it is urgent to find potent topical antibiotics for the use in human and animal infection. Healing of equine wounds, particularly in the limbs, is difficult due to hydrostatic factors and exposure to environmental contaminants, which can lead to heavy bio-burden/biofilm formation and sometimes to infection. Therefore, antibiotics are often prescribed. Recent studies have shown that honeybee-specific lactic acid bacteria (LAB), involved in honey production, and inhibit human wound pathogens.

The aim of this pilot study was to investigate the effects on the healing of hard-to-heal equine wounds after treatment with these LAB symbionts viable in a heather honey formulation. For this, we included ten horses with wound duration of >1 year, investigated the wound microbiota, and treated wounds with the novel honeybee LAB formulation. We identified the microbiota using MALDI-TOF mass spectrometry and DNA sequencing. In addition, the antimicrobial properties of the honeybee LAB formulation were tested against all wound isolates in vitro.


Our results indicate a diverse wound microbiota including fifty-three bacterial species that showed 90 % colonization by at least one species of Staphylococcus. Treatment with the formulation promoted wound healing in all cases already after the first application and the wounds were either completely healed (n = 3) in less than 20 days or healing was in progress. Furthermore, the honeybee LAB formulation inhibited all pathogens when tested in vitro.


Consequently, this new treatment option presents as a powerful candidate for the topical treatment of hard-to-heal wounds in horses. 

The rapid, painless healing of hard-to-heal equine wounds gives us reason to believe that the honeybee LAB formulation presents a new topical option in future wound healing. This new treatment may be a stepping-stone toward an alternative solution for treating other infected wounds in animals and humans and warrants further investigation.