Studies such as this continue to show the value in taking propolis prophylactically to control or regulate certain functions, like hypertension, immunomodulation or antimutogenic, antifungal, anti-inflammatory conditions WITHOUT any adverse side effects...
Role of
Propolis on Tyrosine Hydroxylase Activity and Blood Pressure in Nitric Oxide
Synthase-Inhibited Hypertensive Rats
Clinical and Experimental Hypertension, 2012 April 3
Reduction
in the synthesis or bioavailability of nitric oxide plays a significant role in
the development of hypertension. Propolis is a resinous product collected by
honeybees from various plant sources. Tyrosine hydroxylase (TH) is the
rate-limiting enzyme in the biosynthesis of catecholamines.
The aim of
this study was to examine the effect of propolis on blood pressure (BP), TH,
and total RNA levels in the adrenal medulla, heart, and hypothalamus tissues in
chronic nitric oxide synthase (NOS)-inhibited rats by Nw-nitro-l-arginine
methyl ester (L-NAME).
Rats
received NOS inhibitor (L-NAME) for 15 days to produce hypertension and
propolis for the last 5 days.
TH activity
and total RNA levels significantly increased in adrenal medulla, heart, and
hypothalamus tissues in L-NAME-treated groups. TH activity and total RNA levels
of L-NAME+propolis-treated rats reduced compared with L-NAME-treated groups. TH
activity in propolis-treated rats was reduced to the control values. L-NAME led
to a significant increase in BP compared with the control group. Propolis
administration to L-NAME-treated rats reduced BP but this was not statistically
significant compared to L-NAME-treated groups.
These
results suggest that propolis decreases TH activity in NOS-inhibited
hypertensive rats and thereby may modulate the synthesis of catecholamine and
BP.
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ReplyDeletePropolis administration to L-NAME-treated rats reduced BP but this was not statistically significant compared to L-NAME-treated groups. Venta de Propoleo
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