Royal Jelly is worthy of its name - a product fit for royalty. Professor Eberhard Bengsch has written and studied royal jelly for many years and confirms that within this complex product, honey bees produce proteins very important to human health, such as its antiviral properties and Pantothenic acid, an important ingredient in collagen production. There's more to discover about this rich substance...
Towards
Posttranslational Modification Proteome of Royal Jelly
JProteomics, 2012 June 20
Abstract:
Royal jelly
(RJ) is a secretory protein from the hypopharyngeal glands of nurse honeybee
workers, which contains a variety of proteins of which major royal jelly
proteins (MRJPs) are some of the most important. It plays important roles both
for honeybee and human.
Each family
of MRJP 1-5 displays a string of modified protein spots in the RJ proteome
profile, which may be caused by posttranslational modifications (PTMs) of
MRJPs. However, information on the RJ PTMs is still limited. Therefore, the PTM
status of RJ was identified by using complementary proteome strategies of
two-dimensional gel electrophoresis (2-DE), shotgun analysis in combination
with high performance liquid chromatography-chip/electrospray ionization
quadrupole time-of-flight/tandem mass spectrometry and bioinformatics.
Phosphorylation was characterized in MRJP 1, MRJP 2 and apolipophorin-III-like
protein for the first time and a new site was localized in venom protein 2
precursor. Methylation and deamidation were also identified in most of the
MRJPs.
The results
indicate that methylation is the most important PTM of MRJPs that triggers the
polymorphism of MRJP 1-5 in the RJ proteome. Our data provide a comprehensive
catalog of several important PTMs in RJ and add valuable information towards
assessing both the biological roles of these PTMs and deciphering the
mechanisms underlying the beneficial effects of RJ for human health...
No comments:
Post a Comment