This study demonstrates yet another beneficial effect of Propolis, in that it reduces hypertension and modulates the antioxidant system. The wonderful protective properties of Propolis continue to be documented, expanding an ever-growing list...
Propolis
Reduces Oxidative Stress in l-NAME-Induced Hypertension Rats
Cell Biochemistry and Function, 2013, June 21
The
inhibition in the synthesis or bioavailability of nitric oxide (NO) has an
important role in progress of hypertension. The blocking of nitric oxide
synthase activity may cause vasoconstriction with the formation of reactive
oxygen species (ROS). Propolis is a resinous substance collected by honey bees
from various plants. Propolis has biological and pharmacological properties.
The aim of this study was to examine the effect of propolis on catalase (CAT)
activity, malondialdehyde (MDA) and NO levels in the testis tissues of
hypertensive rats by Nω-nitro-l-arginine methyl ester (l-NAME).
Rats have
received nitric oxide synthase inhibitor (l-NAME, 40 mg kg−1,
intraperitoneally) for 15 days to produce hypertension and propolis (200 mg
kg−1, by gavage) during the last 5 days. MDA level in l-NAME-treated group
significantly increased compared with control group (P < 0.01). MDA level of
l-NAME + propolis-treated rats significantly reduced (P < 0.01) compared
with l-NAME-treated group. CAT activity and NO level significantly reduced
(P < 0.01) in l-NAME group compared with control group. There were no
statistically significant increases in the CAT activity and NO level of the
l-NAME + propolis group compared with the l-NAME-treated group (P > 0.01).
These
results suggest that propolis changes CAT activity, NO and MDA levels in testis
of l-NAME-treated animals, and so it may modulate the antioxidant system.
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