Major discoveries were made last year in researching Royal Jelly, identifying new proteins and compounds that add to its amazing effects on humans and animals. This study gives it further credibility as an ideal supplement for mature adults, providing tonus and energy, supporting brain functions and now enhancing bone quality.
Royal jelly affects collagen crosslinking in bone of
ovariectomized rats
Journal of Functional Foods, 2014 February 11
Royal jelly (RJ) is an essential food for queen bees, and it
reportedly has estrogen-like activity. The objective of this study was to
evaluate the effect of RJ intake on bone quality with a focus on the
posttranslational modifications of type I collagen. RJ was fed to
ovariectomized (OVX) rats for 12 weeks. RJ intake did not affect OVX-induced
reduction in bone volume at the femur epiphysis; however, the reduction of
collagen crosslinks (pyridinoline and deoxypyridinoline), which represent an
aspect of bone quality, were significantly mitigated. In cultured
MC3T3-E1osteoblasts, RJ treatment did not affect cell proliferation, cell
differentiation, matrix formation, or mineralization.
However, RJ treatment did
stimulate expression of plods, which encode lysyl hydroxylase isoforms that
control the collagen crosslinking pathway, and it also affected collagen
crosslinking.
These results indicate that oral intake of RJ could improve
bone quality by modulating the posttranslational modification of type I
collagen.
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