Tuesday, April 29, 2014

Bee Venom Dramatically Reduces ALS Symptoms

This new study finds that Bee Venom Therapy (BVT) has positive results on ALS symptoms, but those who've been using BVT for ALS, MS and various forms of Arthritis can already attest to its benefits. This is promising news for ALS sufferers, as use of the other bee products have been proven to aid and prevent neurodegenerative diseases.

Melittin ameliorates the inflammation of organs in an amyotrophic lateral sclerosis animal model

Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disorder characterized by a selective loss of motor neurons in the spinal cord, brainstem, and motor cortex, leading to weakness of the limb and bulbar muscles. Although the immediate cause of death in ALS is the destruction of motor neurons, ALS is a multi-organ disease that also affects the lungs, spleen, and liver. Melittin is one of components of bee venom and has anti-neuroinflammatory effects in the spinal cord, as shown in an ALS animal model. Melittin is a 26 amino acid protein and is used in traditional Chinese medicine to inhibit cancer cell proliferation and is known to have anti-inflammatory and anti-arthritic effects.

To investigate the effects of melittin on inflammation in the lungs and spleen, we used hSOD1(G93A) transgenic mice that are mimic for ALS. Melittin treatment reduced the expression of inflammatory proteins, including Iba-1 and CD14 by 1.9- and 1.3-fold (p < 0.05), respectively, in the lungs of symptomatic hSOD1(G93A) transgenic mice. In the spleen, the expression of CD14 and COX2 that are related to inflammation were decreased by 1.4 fold (p < 0.05) and cell survival proteins such as pERK and Bcl2 were increased by 1.3- and 1.5-fold (p < 0.05) in the melittin-treated hSOD1G93A transgenic mice. Interestingly, melittin treatment in symptomatic ALS animals improved motor function and reduced the level of neuron death in the spinal cord when compared to the control group

These findings suggest that melittin could be a candidate to regulate the immune system in organs affected by ALSOur research suggests a potential functional link between melittin and the inhibition of neuroinflammation in an ALS animal model.

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