With other studies documenting the anti-aging properties of royal jelly and human trials showing its benefits for age-related conditions, this new study identifies the exact proteins in royal jelly that make it the right product for a long, healthy life.
Royal Jelly-Mediated Prolongevity and Stress Resistance in
Caenorhabditis elegans Is Possibly Modulated by the Interplays of DAF-16,
SIR-2.1, HCF-1, and 14-3-3 Proteins
J Gerontol A Biol Sci Med Sci, 2014 July 29
Recent studies suggest that royal jelly (RJ) and its related
substances may have antiaging properties. However, the molecular mechanisms underlying
the beneficial effects remain elusive.
We report that the effects of RJ and
enzyme-treated RJ (eRJ) on life span and health span in Caenorhabditis elegans
(C elegans) are modulated by the sophisticated interplays of DAF-16, SIR-2.1,
HCF-1, and 14-3-3 proteins. Dietary supplementation with RJ or eRJ increased C.
elegans life span in a dose-dependent manner. The RJ and eRJ consumption
increased the tolerance of C elegans to oxidative stress, ultraviolet
irradiation, and heat shock stress. Our genetic analyses showed that
RJ/eRJ-mediated life-span extension requires insulin/IGF-1 signaling and the
activities of DAF-16, SIR-2.1, HCF-1, and FTT-2, a 14-3-3 protein. Earlier
studies reported that DAF-16/FOXO, SIR-2.1/SIRT1, FTT-2, and HCF-1 have
extensive interplays in worms and mammals. Our present findings suggest that
RJ/eRJ-mediated promotion of longevity and stress resistance in C elegans is
dependent on these conserved interplays.
From an evolutionary point of view,
this study not only provides new insights into the molecular mechanisms of RJ's
action on health span promotion in C elegans, but also has imperative
implications in using RJ/eRJ as nutraceuticals to delay aging and age-related
disorders.
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