Interest in propolis is mounting rapidly and its role as an adjuvant is a consistent finding in complementary and alternative therapies. Moreover, its ability to cause cell death or apoptosis in tumor cells is irreproachable, especially considering that it has no negative side effects.
The findings obtained so far build hope that propolis
as a complementary medicine may address the lacunae. This review documents the
recent advances and scope of amendement in cancer remediation with adequate
emphasis on the mechanistic aspect of propolis.
Emerging Adjuvant Therapy for Cancer: Propolis and its
Constituents
J Diet Suppl. 2015 Feb 27. [Epub ahead of print]
Propolis is a bee-metabolized resinous substance (bee glue)
from plant sap and gums. It has been in usage as a healing agent since
antiquity, yet has not garnered global popularity as a health promoter. Its
biological effects, which range from antimicrobial, antioxidant,
anti-inflammatory, antidiabetic, dermatoprotective, anti-allergic, laxative and
immunomodulatory to anticancer, have been validated.
Propolis has shown efficacy against brain, head and neck,
skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood
cancers.
The inhibition of matrix metalloproteinases,
anti-angiogenesis, prevention of metastasis, cell-cycle arrest, induction of
apoptosis and moderation of the chemotherapy-induced deleterious side effects
have been deduced as the key mechanisms of cancer manipulation. The components
conferring antitumor potentials have been identified as caffeic acid phenethyl
ester, chrysin, artepillin C, nemorosone, galangin, cardanol, etc. These
compounds target various genetic and biochemical pathways of cancer
progression. Depending on the botanical sources and the geographical origin,
biological activities of propolis vary. Despite phenomenal development in
cancer research, conventional therapy falls short in complete malignancy
management.
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