The importance of Propolis is its capacity to be complementary, enhancing the effects of antibiotics and other medication, while at the same time healing damaged tissue.
Protective effects of Chinese and Brazilian propolis treatment against hepatorenal lesion in diabetic rats
College of Animal Sciences, Zhejiang University; Hum Exp Toxicol Sept 2011 vol. 30
Protective effects of Chinese and Brazilian propolis treatment against hepatorenal lesion in diabetic rats
College of Animal Sciences, Zhejiang University; Hum Exp Toxicol Sept 2011 vol. 30
Abstract
Diabetes mellitus promoted an overproduction of free
radicals and an increased incidence of both diabetic nephropathy and liver
disease. In this report, we evaluated the effects of Chinese and Brazilian
propolis on streptozotocin-induced hepatorenal injury in rats.
The results demonstrated that Chinese propolis-treated
rats had a 7.4% reduction in the glycated hemoglobin (HbAlc) level compared
with untreated diabetic rats. Additionally, Chinese propolis induced an
increase in the serum superoxide dismutase (SOD) level significantly while
Brazilian propolis raised serum SOD and reduced level of malonaldehyde (MDA)
and nitric synthetase (NOS). Of the measurable decrease in serum alanine transaminase
(ALT), aspartate transaminase (AST) and microalbuminuria demonstrated the
propolis-mediated improvement of hepatorenal function, which was further
confirmed by histological examination.
We also observed that Chinese and Brazilian propolis
increased hepatorenal glutathione peroxidase (GSH-px) level and inhibited MDA
production significantly. These results suggested that propolis may prevent
hepatorenal injury by inhibiting lipid peroxidation and enhancing the
activities of antioxidant enzymes.
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