The anti-tumor effects of Propolis are verified once again in detail. This protector of the beehive is the natural protector for all mankind and all in the animal kingdom...
The
Anticancer Activity of Propolis
FoliaHistochem Cytobiol, 2012 Apr
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[click here for full pdf]
Abstract:
Propolis
and its compounds have been the subject of many studies due to their
antimicrobial and antiinflammatory activity; however, it is now known that they
also possess antitumor properties.
This review
aims to summarize the results of studies on the mechanism of activity of
propolis and its active compounds such as CAPE
and chrysin in the apoptotic process, and their influence on the proliferation
of cancer cells.
Our review
shows that propolis and its presented compounds induce apoptosis pathways in cancer
cells. The antiproliferative effects of propolis, CAPE
or chrysin in cancer cells are the result of the suppression of complexes of
cyclins, as well as cell cycle arrest.
The results
of in vitro and in vivo studies suggest that propolis, CAPE
and chrysin may inhibit tumor cell progression and may be useful as potential
chemotherapeutic or chemopreventive anticancer drugs...
Conclusion:
With
an increasing incidence rate of cancer worldwide, new anticancer agents are
still required. One of the benefits of anticancer therapy is the ability to
initiate apoptosis and cell cycle arrest in cancer cells. The studies presented
in this review suggest that propolis and its compounds, CAPE
and chrysin, may inhibit cell cycle proliferation or induce apoptosis in tumor
cells...
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