Royal Jelly also has a stimulating, activating effect on the central nervous system and shows neurotrophic effects on the mature brain....
Royal Jelly Can Diminish Secondary Neuronal Damage After Experimental Spinal Cord Injury in Rabbits
Food ChemToxicol, 2012 Apr 17
The aim of this experimental study was to investigate the neuroprotective effect of Royal jelly (RJ) on traumatic spinal cord injury (SCI).
male rabbits, weighing between 2.5 and 3.0kg were divided into three groups:
Sham (no drug or operation, n=7), Control (laminectomy+single dose of 1ml/kg
saline orally, after trauma; n=7) and RJ (laminectomy+100mg/kg RJ, orally,
after trauma, n=7). Laminectomy was performed at T10 and balloon catheter was
applied extradurally for traumatic SCI. Four and 24h after surgery, rabbits
were evaluated according to the Tarlov scoring system. Blood, cerebrospinal
fluid and tissue sample from spinal cord were taken for measurements of
antioxidant status or detection of apoptosis. Four hours after SCI, all animals
in control or RJ treated groups became paraparesic. New Zealand
Significant improvement was observed in RJ treated group, 24h after SCI, with respect to control.
Traumatic SCI led to increase in the lipid peroxidation and decrease enzymic or non-enzymic endogenous antioxidative defense systems, and increase in apoptotic cell numbers.
RJ treatment mostly prevented lipid peroxidation and also augmented endogenous enzymic or non-enzymic antioxidative defense systems. Again, RJ treatment significantly decreased the apoptotic cell number induced by SCI.