Once again, Propolis demonstrates its numerous qualities of protecting life of not only humans, but animals as well. Hopefully, there'll be a follow up to this study to determine what dose would be effective in vivo, since it's impossible to overdose on Propolis...
Susceptibility
of Trypanosoma evansi to Propolis Extract in vitro and in Experimentally
Infected Rats
Research in Veterinary Science, 2012, December,
Current
therapy of Trypanosoma evansi infections is not effective for the vast majority
of animals with relapsing parasitemia and clinical signs. Recently, attention
is being focused on the antiparasitic activity of propolis.
This study
evaluated the susceptibility of T. evansi to propolis extract in vitro and in
vivo.
A
dose-dependent trypanocidal activity of propolis extract was observed in vitro.
All trypomastigotes were killed 1 h after incubation with 10 μg mL−1 of the
extract. In vivo, the concentrations of 100, 200, 300 and 400 mg kg−1
administered orally for 10 consecutive days showed no curative effect, and the
rats died from the disease. However, rats treated with the two highest
concentrations of propolis extract showed higher longevity than the other
groups.
Based on
these data, we concluded that T. evansi is susceptible to propolis in vitro.
Despite the lack of curative efficacy observed in vivo at the concentrations
tested, the propolis extract can prolong life in rats infected with the
protozoan.
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