Propolis possesses numerous bioflavonoids and Galangin is commonly found in Propolis from the Northern Hemisphere in areas with Poplar trees. Yet this anti-cancerous characteristic is consistently present with all Propolis, since there are other bioflavonoids which possess this capacity...
Galangin
Induces B16F10 Melanoma Cell Apoptosis Via Mitochondrial Pathway and Sustained
Activation of p38 MAPK
Cytotechnology,
2012 Sep 22
Galangin,
an active flavonoid present at high concentration in Alpinia officinarum Hance
and propolis, shows cytotoxicity towards several cancer cell lines, including
melanoma. However, the specific cellular targets of galangin-induced
cytotoxicity in melanoma are still unknown.
Here, we
investigated the effects of galangin in B16F10 melanoma cells and explored the
possible molecular mechanisms. Galangin significantly decreased cell viability
of B16F10 cells, and also induced cell apoptosis shown by Hoechst 33342
staining and Annexin V-PI double staining flow cytometric assay.
Furthermore,
upon galangin treatment, disruption of mitochondrial membrane potential was
observed by JC-1 staining. Western blotting analysis indicated that galangin
activated apoptosis signaling cascades by cleavage of procaspase-9,
procaspase-3 and PARP in B16F10 cells. Moreover, galangin significantly induced
activation of phosphor-p38 MAPK in a time and dose dependent manner. SB203580,
an inhibitor of p38, partially attenuated galangin-induced apoptosis in B16F10
cells.
Taken
together, this work suggests that galangin has the potential to be a promising
agent for melanoma treatment and may be further evaluated as a chemotherapeutic
agent.
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