I've always said that bee stings were like booster shots. This is seriously good news for those receiving cancer treatment - added protection for kidneys against negative side effects of potent drugs. If you're also in that situation, taking propolis is highly recommended, as it has a protective effect on the liver against toxins, not to mention its immune system supportive activity...
These results suggest that BV has protective
effects on cisplatin-induced nephrotoxicity in mice, at least in part, through
the regulation of Tregs without a big influence on the antitumor effects of
cisplatin.
Bee Venom
Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4(+)CD25(+)Foxp3(+)
Regulatory T Cells in Mice
Evid BasedComplement Alternat Med, 2013, Vol 2013, Art ID 879845
Cisplatin
is used as a potent anticancer drug, but it often causes nephrotoxicity. Bee
venom (BV) has been used for the treatment of various inflammatory diseases,
and its renoprotective action was shown in NZB/W mice. However, little is known
about whether BV has beneficial effects on cisplatin-induced nephrotoxicity and
how such effects might be mediated. In the present study, the BV-injected group
showed a significant increase in the population of Tregs in spleen. Although
there was no significant difference in the numbers of Tregs 3 days after
cisplatin injection between the BV- and PBS-injected groups, more migration of
Tregs into the kidney was observed 6 hours after cisplatin administration in BV
group than in PBS group. In addition, BV-injected mice showed reduced levels of
serum creatinine, blood urea nitrogen, renal tissue damage, proinflammatory
cytokines, and macrophage infiltration into the kidney 3 days after cisplatin
administration. These renoprotective effects were abolished by the depletion of
Tregs. The anticancer effect of repeated administrations of cisplatin was not affected
by BV injection.
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