Propolis has a protective effect on humans and animals and its not just in the liver that it provides protection but throughout the intestinal tract. And that's just part of the story - it also has other important values to aid living beings...
Protective
Effects of Propolis on Female Rats’ Histopathological, Biochemical and
Genotoxic Changes During LPS Induced Endotoxemia
Phytomedicine, 2013, February 27
In recent
years, propolis has been the object of extensive research for its antibacterial,
antioxidant, anti-inflammatory, and antitumoral activities. This study aims to
determine the hepatoprotective efficiency of propolis on experimental
endotoxemia in rats.
In the
current study, fifty adult Sprague Dawley rats (weighing 200–300 g) were randomly
divided into five groups of ten rats each. Normal saline solution was
administered to the rats in the control group, while in the second group LPS
(30 mg/kg), in the third group propolis (250 mg/kg), in the fourth group first
propolis and then LPS (30 mg/kg), and in the fifth group, first LPS (30 mg/kg)
and then propolis were given. Six hours after the application, biochemical (MDA
levels) and histopathological changes as well as global DNA methylation
analysis in the liver tissue samples were determined, while in the blood tissue
samples Genomic Template Stability (GTS, %) was evaluated using RAPD-PCR
profiles.
The results
demonstrated that the administration of propolis could have a protective effect
against changes of both genomic stability values and methylation profiles, and
it minimized the increase in MDA and tissue damage caused by LPS.
In conclusion, the application of propolis prior to
LPS-induced endotoxemia has shown to reduce hepatic damage.
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