Propolis, a natural protector for all species, works equally well both internally and externally. This study confirms yet another important aspect of one of its many flavonoids, CAPE, which strengthens the body's capacity to heal bone fractures faster, thanks to its antioxidant and anti-inflammatory properties...
Influence
of caffeic acid phenethyl ester on bone healing in a rat model
J Intl Medical Research, 2013 Sep 24
OBJECTIVE:
To examine
the effects of caffeic acid phenethyl ester (CAPE; a component of honey
bee-hive propolis with antioxidant, anti-inflammatory, antiviral and anticancer
properties) on bone regeneration and fibrotic healing in a rat model.
METHODS:
Male
Sprague-Dawley rats (n = 63; mean age 7 weeks; weight 280-490 g) were randomly
divided into three groups: A, cranial defect with no bone healing treatment
(n = 21); B, cranial defect treated with CAPE (n = 21); C, cranial defect
treated with CAPE and β-tricalcium phosphate/hydroxyl apatite (n = 21). Rats were
anaesthetized with ketamine (8 mg/100 g) by intraperitoneal injection and a
cranial critical size bone defect was created. Following surgery, CAPE
(10 µmol/kg) was administered by daily intraperitoneal injection. Seven rats in
each group were killed at days 7, 15 and 30 following surgery. Bone
regeneration, fibrotic healing and osteoblast activity were evaluated by
histopathology.
RESULTS:
Statistically
significant differences in healing were found between all groups. There were no
statistically significant within-group differences between day 7 and 15. At day
30, bone healing scores were significantly higher in groups B and C compared
with group A.
CONCLUSION:
CAPE significantly improved bone-defect healing in
a rat model, suggesting that CAPE has beneficial effects on bone healing.
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