Propolis, already documented to be effective in treating psoriasis, has a new study which relied on thermography to validate its anti-inflammatory action against common irritants. Furthermore, propolis did not generate any negative side effects...
Inhibitory
effect of a propolis on Di-n-Propyl Disulfide or n-Hexyl salicilate-induced
skin irritation, oxidative stress and inflammatory responses in mice
PURPOSE:
Thermal
imaging has been utilized, both preclinically and clinically, as a tool for
assessing inflammation. Psoriasis is a chronic inflammatory skin disease
characterized by hyperkeratosis, dermal inflammatory infiltrate and increased
angiogenesis. The aim of the present study was to assess usefulness of
thermography in psoriatic lesion regression after topical treatment with bee
propolis, recognized as potent antioxidants and anti-inflammatory agents.
METHODS:
We
monitored the inflammation process induced by irritants such as n-Hexyl
salicilate (HXS) or Di-n-Propyl Disulfide (PPD) by hystopatological assement of
skin, thermographic scanning, total number of inflammatory cells in peritoneal
cavity, differential analysis of cells in peritoneal cavity, macrophage
spreading index, haematological and biochemical parameters, frequencies of
micronucleated reticulocytes, lipid peroxidation and glutathione assay in skin.
RESULTS:
Topically
applied ethanolic extract of propolis (EEP) with HXS or PPD reduced the lipid peroxidation in skin and total number of inflammatory cells in skin and peritoneal cavity, functional activity of macrophages, the number of
micronuclei in mouse peripheral blood reticulocytes and enzymatic activity of
ALP and AST.
CONCLUSION:
These
results demonstrate that topical application of EEP may improve psoriatic-like
skin lesions by suppressing functional activity of macrophages and ROS
production. Taken together, it is suggested that EEP can safely be utilized in
the prevention of psoriasis-related inflammatory changes without causing any
toxic effect.
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