Just one of numerous flavonoids found in propolis and in smaller doses in honey, Chrysin has been found to protect cells from lab-induced ammonia intoxication. The protective effects of this flavonoid is a common trait with propolis, where we find it always protecting and healing various conditions as well as preventing damaging effects from chemicals, drugs, pesticides, etc.
On the other hand
increased level of plasma urea was observed in chrysin treated rats as compared
with hyperammonemic rats. Chrysin administration caused distortion of hepatic,
brain and kidney architecture as shown by histological examination.
Chrysin at a dose (100mg/kg b.w.) showed an
utmost decline in the level of all biochemical estimations. Both biochemical
and morphological studies clearly revealed that chrysin protects against cell
injury induced by ammonia intoxication in a
dose-response manner with respect to endogenous antioxidants and hypoammonemic
effects.
Biomed Pharmacother. 2016 May 24;82:345-354
Chrysin (5,7-dihydroxyflavone) is a major component
of some traditional medicinal herbs present in honey, propolis and many plant
extracts.
The study was aimed to illuminate the effect of
chrysin in the pathogenesis of ammonium chloride (NH4Cl) induced hyperammonemic
rat model in a dose dependent manner. Rats were injected with NH4Cl (100mg/kg
b.w.) by intraperitonially (i.p) thrice a week for 8 consecutive weeks for the
induction of experimental hyperammonemia. Hyperammonemic rats were treated with
chrysin by orally at a dose of 25, 50 & 100mg/kg b.w. respectively.
Protective effect of chrysin against hyperammonemia was evaluated by performing
biochemical estimations and morphopathological investigations of hematoxylin
and eosin stained sections of liver, brain and kidney tissues. Supplementation
of chrysin reinstated the levels of blood ammonia, plasma urea, uric acid,
total bilirubin, creatinine, brain glutamate, glutamine, nitric oxide (NO) and
the activities of Na+/K+-ATPase, and liver marker enzymes.
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