Bee venom, the most feared of all bee products, is advancing in the beauty sector, offering a natural alternative to rejuvenating the skin and now as a natural acne treatment. A separate study last year found the same positive results in treating acne...
The
protective effects of melittin on Propionibacterium acnes-induced inflammatory
responses in vitro and in vivo
J InvestDermatol, 2014 Feb 4
Abstract:
Melittin is
the main component in the venom of the honey bee (Apis mellifera). It has
multiple effects including anti-bacterial, anti-viral, and anti-inflammatory
activities, in various cell types. However, the anti-inflammatory mechanisms of
melittin have not been elucidated in Propionibactierium acnes (P. acnes)
induced keratinocyte or inflammatory skin disease animal models.
In this study,
we examined the effects of melittin on the production of inflammatory cytokines
in heat-killed P. acnes-induced HaCaT cells. Heat-killed P. acnes treated
keratinocytes increased the expression of pro-inflammatory cytokines and toll
like receptor 2. However, melittin treatment significantly suppressed the
expression of these cytokines through regulation of the NF-κB and MAPK
signaling pathways.
Subsequently, we examined the living P. acnes (1 × 107 CFU)
were intradermally injected into the ear of mice. Living P. acnes injected ears
showed cutaneous erythema, swelling, and granulomatous response at 24 h after
injection. However, melittin-treated ears showed markedly reduced swelling and
granulomatous responses compared with ears injected with only living P. acnes.
These results demonstrate the feasibility of applying melittin for the prevention
of inflammatory skin diseases induced by P. acnes.
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