We normally see royal jelly supporting the nervous and cardiovascular systems, horomonal production and boosting vitality. Surprisingly, this study found it also protects from the negative side effects of a chemotherapy drug, as well as sperm viability. Amazing as it seems, bee products have a capacity of not only protecting but enhancing our health...
Royal jelly
protects from taxol-induced testicular damages via improvement of antioxidant
status and up-regulation of E2f1
Syst Biol Reprod Med, 2013 Dec
This study
was carried out to evaluate the protective effects of royal jelly (RJ) on taxol
(TXL)-induced damage of the testis.
Wistar rats were divided into control and
test groups. The test group was divided into five subgroups; the first four
groups along with TXL administration (7.5 mg/kg body weight (bw), weekly),
received various doses of RJ (0, 50, 100, and 150 mg/kg bw). The last group
received only RJ at 100 mg/kg. Royal jelly lowered the TXL-induced
malondialdehyde and nitric oxide levels and enhanced the total thiol molecules
in the testis. Remarkably RJ reduced the TXL-induced pathological injuries such
as cellular shrinkage and seminiferous tubule depletion. Taxol-reduced sperm
viability (27.5 ± 2.98 % vs. 85.0 ± 8.6% in the control group) was recovered by
RJ administration as 80.5 ± 10.6% of the sperm were found alive in the group of
animals which received 150 mg/kg RJ. The TXL-exposed and TXL plus
RJ-administered animals showed a significant up-regulation of transcription
factor E2f1 mRNA.
Our data
suggest that the TXL-induced histopathological and biochemical alterations
could be protected by the administration of RJ. The RJ protective effects might
be attributed to its antioxidant capacity and its capability in the regulation
of E2f1 expression.
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