Propolis is the natural protector for humans and animals. It's been proven in numerous studies to protect the body from commonly occuring illnesses, as well as more toxic situations, such as this example. You'll find even more references to its protective nature with other internal organs such as the liver and the intestines in this blog...
It can be concluded that propolis may be promising as a natural therapeutic agent in AlCl(3) -induced renal toxicity and oxidative stress in rat kidneys.
Role of
Propolis (Bee Glue) in Improving Histopathological Changes of the Kidney of Rat
Treated with Aluminum Chloride
EnvironToxicol, 2012 Nov 22
Humans are
frequently exposed to aluminum from various food additives, therapeutic
treatments and the environment, and it can be potentially toxic. This study
is aimed to elucidate the protective effects of propolis against aluminum
chloride (AlCl(3) )-induced histopathological and immunohistochemical changes
in kidney tissues of rats.
Sixty Wistar Albino male rats (average weight
250-300 g) were divided into three equal groups. The first served as a negative
control. The second received AlCl(3) (34 mg/kg bw, 1/ 25 LD 50). The third were
administered AlCl(3) (34 mg/kg bw, 1/ 25 LD 50) plus propolis (50 mg/kg bw).
Doses were given once daily via a gavage for 8 weeks every day.
The results
showed that shrunken glomeruli, intraglomerular congestion, loss of apical
microvilli, degeneration of mitochondria and widened rough endoplasmic
reticulum were also observed in the Proximal Convoluted Tubules of these
animals. Treatment with propolis ameliorated the harmful effects of AlCl(3) ;
this was also proved histopathologically by the noticeable improvement in the
renal tissues. There were also significant variations in the expressed of ki-67
and p53 proteins.
It can be concluded that propolis may be promising as a natural therapeutic agent in AlCl(3) -induced renal toxicity and oxidative stress in rat kidneys.
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