Apimondia
Apimedica-Apiquality International Forum
Acute
Toxicological Test of Propolis
2012, Oct. 22-25 Zhenjiang, China
ZHUO
Bi-rong, SHI Pei-ying, WU Zhen-hong*
(Bee
Science College of Fujian Agriculture and Forestry University, State and Local
Joint Engineering Laboratory of Natural Biotoxi, Fuzhou 350002, China )
This
project used Fixed-dose procedure to study acute toxicity reaction of mice to
ethanol extract of propolis. The result showed that mice, which have been
lavaged with ethanol extract of propolis were all live during 0~14 days. In
addition, the tested mice shown no-affected locomotor activity and had no
abnormal symptoms. The mice showed no abnormal secretion in mouths, noses and
ears. Also the mice showed other normal symptoms such as eyelid without
prolapse, clear eye pupil, normal excretions, and smooth hair. Autopsy results
showed no obvious abnormity characterization of the organs. The organs index
has no obvious difference with control group (The max dose is 2000mg/kg).
In
conclusion, mice had no acute toxicity reaction to ethanol extract of propolis.
Since 2000mg/kg is 100 times of the human body recommended dose, people can
also use propolis with this dose.
*Corresponding
author, E-mail:wzh516@126.com