Propolis, rich in numerous polyphenols with unique therapeutic values makes this bee product the most researched worldwide. This randomized placebo-controlled clinical study of Azerbaijan propolis proved it to be an important adjuvant therapeutic with impressive results. Interestingly enough, this anti-depressive characteristic has been identified in previous studies.
Propolis add-on therapy alleviates depressive symptoms; A randomized placebo-controlled clinical trial
was a significant reduction in HAMD score in the propolis group compared with the placebo group (p < .0001). HAMD score significantly decreased in the propolis group from 20.92 ± 3.77 on D0 to 10.03 ± 5.55 on D42, and BDI score was improved from 29.25 ± 3.06 on D0 to 14.17 ± 4.86 on D42. Our findings confirmed that complementary treatment of propolis with SSRIs could safely attenuate symptoms of moderate–severe MDD. These antidepressant effects might result from the rich phenolic acids and flavonoids content of Azerbaijan propolis.