Another new finding confirming the ability of propolis to protect the kidneys. This is consistent with other studies which find that it not only prevents, protects and heals the kidneys, but the liver and spleen as well. The anti-inflammatory, antioxidant and wound-healing capacities are a welcome addition, internally and externally.
Brazilian Red Propolis Attenuates Hypertension and Renal
Damage in 5/6 Renal Ablation Model
PLoS One. 2015 Jan 21;10(1):e0116535
The pathogenic role of inflammation and oxidative stress in
chronic kidney disease (CKD) is well known. Anti-inflammatories and antioxidant
drugs has demonstrated significant renoprotection in experimental
nephropathies. Moreover, the inclusion of natural antioxidants derived from
food and herbal extracts (such as polyphenols, curcumin and lycopene) as an
adjuvant therapy for slowing CKD progression has been largely tested. Brazilian
propolis is a honeybee product, whose anti-inflammatory, antimicrobial and
antioxidant effects have been widely shown in models of sepsis, cancer, skin
irritation and liver fibrosis. Furthermore, previous studies demonstrated that
this compound promotes vasodilation and reduces hypertension. However,
potential renoprotective effects of propolis in CKD have never been
investigated.
The aim of this study was to evaluate the effects of a
subtype of Brazilian propolis, the Red Propolis (RP), in the 5/6 renal ablation
model (Nx). Adult male Wistar rats underwent Nx and were divided into untreated
(Nx) and RP-treated (Nx+RP) groups, after 30 days of surgery; when rats already
exhibited marked hypertension and proteinuria. Animals were observed for 90
days from the surgery day, when Nx+RP group showed significant reduction of hypertension,
proteinuria, serum creatinine retention, glomerulosclerosis, renal macrophage
infiltration and oxidative stress, compared to age-matched untreated Nx rats,
which worsened progressively over time.
In conclusion, RP treatment attenuated hypertension and
structural renal damage in Nx model. Reduction of renal inflammation and
oxidative stress could be a plausible mechanism to explain this renoprotection.
