This study reaffirms once again, the holistic effects of propolis on mucous linings of the body, in particular the nasal passageway. Its anti-inflammatory properties also provide anti-allergic effects, ideal for those who suffer from respiratory ailments. Just another amazing product made by honeybees.
Effects of propolis in an experimental rat model of allergic
rhinitis
Purpose
The aim of this study was to determine the anti-allergic
activity of propolis in an ovalbumin-induced rat model of allergic rhinitis.
Materials and methods
This prospective experimental study was conducted at Hakan
Çetinsaya Clinical and Experimental Animal Research Center with 30 rats. After
sensitization of all rats with 0.3 mg intraperitoneal ovalbumin plus 30 mg
aluminum hydroxide for 14 days (first phase), rats were divided to five groups.
In the second phase of the study 10 μL of ovalbumin was applied to each nostril
for 21 days. Together with second phase, ketotifen (n:6), oral propolis (n:6),
intranasal propolis (n:6) and intranasal mometasone furoate (n:6) were given to
rats. A control group (n:4)(salin) and sham group (n:2) were planned. Symptoms
were assessed on days 19, 22, 25, 30 and 35, resulting in 5 symptom scores:
symptom scores 1–5. On day 35, nasal tissue was removed and histological
examination was performed.
Results
When rats that received systemic and intranasal propolis
were compared to controls, ciliary loss, inflammation, increase in goblet
cells, vascular proliferation, eosinophil count, chondrocytes and allergic
rhinitis symptom score were found to be decreased (p < 0.05).
Conclusions
It was found that propolis had anti-allergic effects on
allergic symptom scores and nasal histology.
