Propolis is a proven, preventative solution for cancer. CAPE is one of several flavonoids which exhibit anti-tumor properties. Other flavonoids which express the same activity include chrysine, quercetin, artepillin C, Methyl caffeate, Methyl feruleate and Diterpendoid of clerodan...
Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks
Cancer PrevRes 2012 May 1
Caffeic acid phenethyl ester (
CAPE) is a bioactive
component derived from honeybee hive propolis. CAPE
has been shown to have antimitogenic, anticarcinogenic, and other beneficial
medicinal properties. Many of its effects have been shown to be mediated
through its inhibition of NF-κB signaling pathways.
We took a systematic approach to uncover the effects of
from hours to days on the signaling networks in human prostate cancer cells. We
observed that CAPE dosage dependently
suppressed the proliferation of LNCaP, DU-145, and PC-3 human prostate cancer
cells. Administration of CAPE by gavage
significantly inhibited the tumor growth of LNCaP xenografts in nude mice.
Using LNCaP cells as a model system, we examined the effect of CAPE on gene expression, protein signaling, and
transcriptional regulatory networks using micro-Western arrays and PCR arrays.
We built a model of the impact of
CAPE on cell signaling
which suggested that it acted through inhibition of Akt-related protein
signaling networks. Overexpression of Akt1 or c-Myc, a downstream target of Akt
signaling, significantly blocked the antiproliferative effects of CAPE.
In summary, our results suggest that
may be useful as an adjuvant therapy for prostate and potentially other types
of cancers that are driven by the p70S6K and Akt signaling networks.