Saturday, August 6, 2011

Royal Jelly May Help Treat Depression and Anxiety

This research confirms what has been noted before of Royal Jelly's overall positive tonic effect ...

Antidepressant-Like Activity of 10-hydroxy-trans-2-decenoic acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model
Evid Based Complement Alternat Med, 2012;2012:139140. Epub 2011 Jul 24

Royal jelly (RJ), which is fed to the queen honeybee, has a variety of biological activities towards various types of cells. For instance, RJ exhibits immunomodulatory properties [1–3] and inhibits the development of atopic dermatitis-like skin lesions [4]....

Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. 

The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. Using these experimental systems, we found that 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the stress loading. Intraperitoneally administered RJ, a rich source of HDEA, was also protective against the depression, but RJ given by the oral route was less effective...

 These results demonstrate that HDEA and RJ, a natural source of it, are effective in ameliorating the stress-inducible symptoms of depression and anxiety and suggest that they may become a promising tool as a new antidepressant.


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  2. Thank you Mukesh. It's true that combining bee products has a synergistic affect that heals bodies better together.